Horario de atención: Lunes a Viernes - 8:00 - 12md y de 1:00 - 5:00pm

Laboratorio de Investigación en Biorrefinería

LIB

Publicaciones del grupo:

Ana Francis Carballo:

Carballo-Arce, Ana Francis; Rocha, Marco; Saikaley, Amanda; Liu, Rui; Otarola, Marco; Poveda, Luis; Sanchez, Pablo; García, Mario; Coelho Kaplan, María Auxiliadora; Durst, Tony, Arnason, Thor. Familia Marcgraviaceae: fitoquímica y actividad Biológica. Presentación Oral. 2014. Congreso SILAE. Costa Rica.
Durst, Tony; Baker, John Douglas; Arnason, John Thor; Wade, Jose Miguel; Merali, Zulfiquar; Mullallly, Martha; Cayer, Christian; Alkemade, StandleyJ.; Carballo, Ana Franciselji, I. (2014). Plant compositions and methods and uses thereof for treting elevated glucocorticoid related disorders and anxiety. PatentePTC/CA2013/000950, WO2014/071507 A1
Carballo-Arce, A. F., Ta, C. A. K., Rocha, M. E. do N., Liu, R., Harmsen, I., Mogg, C. D., Arnason, J. T. (2015). Antimicrobial activities of Marcgraviaceae species and isolation of a naphthoquinone from Marcgravia nervosa (Marcgraviaceae). Botany, 93(7), 413–424. http://doi.org/10.1139/cjb-2015-0038
Rui Liu, Fida Ahmed, Christian Cayer, Martha Mullally, Ana Francis Carballo, Marco Otarola Rojas, Mario Garcia, John Baker, Aleksandar Masic, Pablo E Sanchez, Luis Poveda, Zul Merali, Tony Durst, and John T. Arnason. (2017). New Botanical Anxiolytics for Use in Companion Animals and Humans. AAPS, 19(6), 1626-1631.
R. Liu, A-F. Carballo-Arcea, R. Singha , A. Saleemb, M. Rachael. M. Mullally, M. Otarola-Rojasd, L. Poveda Alvarrezd, P. Sanchez-Vindasd, M. Garciad, J. Bakerf, Z. Meralig, J-A. Guerrero-Analco , T. Durst, C. Harrisa, JT. Arnason. A Selective Ion HPLC-APCI-MS Method for the Quantification of Pentacyclic Triterpenes in an Anxiolytic Botanical Dietary Supplement for the Animal Health Market. Natural product Communications. Vo.13. 2018.
Ana Francis Carballo-Arc e, Vikrant Raina, Suqi Liu, Rui Liu, Victoria Jackiewicz,
David Carranza, John Thor Arnason, and Tony Durst. Potent CYP3A4 Inhibitors Derived from Dillapiol and Sesamol. ACS Omega 2019, 4, 10915−10920
Adriana Zúñiga-Meléndez, Alejandro Durán-Apuy, Jesennia Chavarría-Vásquez, Ronny Gamboa-Araya, Ana Francis Carballo-Arce, Xinia Vargas-González, Nelson Campos-Quesada, Cecilia Sevilla-Solano, Isabel Torres-Salas (2020) Diagnóstico de las necesidades de capacitación de docentes de biología, química, física y matemática, en áreas disciplinares, pedagógicas, y uso de las tecnologías para la promoción de habilidades de pensamiento científico. Educare vol.24 n.3.

Humberto Trimiño:

Pazos, L., H. Trimiño y J. Mata-Segreda. (1978) "Activity of S-octylthiouronium chloride in
aqueous solution". Ing. Cien. Quim. 2 (4) 31-34.
Montenecourt, B.S., S.M. Cuskey, S.D. Nhlapo, H. Trimiño-Vázquez y D.E. Eveleigh (1981) "Strain development for the production of microbial cellulases". En Vol.3. Biosynthesis & Biodegradation of Wood Components. International Symposium on Wood and Pulping Chemistry. Stockholm., Sweden. IUPAC. Ekman-Days. pp. 43-50.
Montenecourt B.S., Nhlapo S.D., Trimiño-Vazquez H., Cuskey S., Schamhart D.H.J., Eveleigh D.E. (1981) “Regulatory Controls in Relation to Overproduction of Fungal Cellulases.” In: Hollaender A., Rabson R., Rogers P., Pietro A.S., Valentine R., Wolfe R. (eds) Trends in the Biology of Fermentations for Fuels and Chemicals. Basic Life Sciences. Springer, Boston, MA. pp 33-53.
Ghosh, A., S.A. Al-Rabiai, B.K. Ghosh, H. Trimiño-Vazquez, D.E. Eveleigh and B.S. Montenecourt (1982) "Increased endoplasmic reticulum content of mutant of Trichoderma reesei (RUT C-30) in relation to cellulase synthesis". Enzyme Microb. Technol. 4 (2) 110-113.
Ghosh, A., B.K. Ghosh, H. Trimiño-Vazquez, D.E. Eveleigh and B.S. Montenecourt (1982) "Cellulase secretion from a hypercellulolytic mutant of Trichoderma reesei RUT C- 30". Arch. Microbiol. 140 (2-3) 126-133.
Trimiño-Vázquez, H. (1984) "Biotecnología en la Industria" En "Setiembre Científico 1983" UNED pp 49-62.
Trimiño, H., L. Pazos-Sanou (1985) "Partial molar volume of S-octylthiouronium chloride in aqueous solution at 37 degree C" Ing. Cienc. Quim. 9 (2) 47-48.
Madrigal-Villa, H., Trimiño-V., H., Carballo-A., J.E. (1992) “Actividad proteolítica en latex de Jathropa aconitofolia” REVITECA 1 (1): 34-40.
Borbón, H., J. M. Herrera, M. Calvo, H. Trimiño, L. Sierra, R. Soto, I. Vega (2012) “Antimicrobial Activity Of Most Abundant Marine Macroalgae Of The Caribbean Coast Of Costa Rica”, Journal of Asian Scientific Research, Vol. 2, No. 5, pp. 292-299.
Bagnarello, V., H. Borbón, M. Calvo, H. Trimiño, J. Alpíza-Cordero (2014) “Isolation and Chemical Characterization of Two New Anthocyanin Pigments from Güiscoyol (Bactris guineensis) Fruit”, European Journal of Scientific Research, Vol. 127, No. 4, pp. 369-381.
Syedd-León, R., Sandoval-Barrantes. M., Trimiño-Vásquez, H., Villegas-Peñaranda, L, Rodríguez-Rodríguez, G. (2020) “Revisiting the fundamentals of p-nitrophenol analysis for its application in the quantification of lipases activity. A graphical update.” UNICIENCIA 34 (2) 31-43.
Mora-Villalobos, J.A., F. Aguilar, A.F. Carballo-Arce, J.R. Vega-Baudrit, H. Trimino-Vazquez, L.R. Villegas-Peñaranda, A. Stöbener, D. Eixenberger, P. Bubenheim, M. Sandoval-Barrantes & A. Liese (2021) “Tropical agroindustrial biowaste revalorization through integrative biorefineries—review part I: coffee and palm oil by-products” Biomass Conv. Bioref. 2021: 19 pgs.
Degen, R.J., F. Bejarano-Castillo, P. Rodríguez-Acosta, H Trimino-Vásquez (2008) “Load Bearing Wall Formwork System and Method” World Intellectual Property Organization - International Publication Number WO 2008/0441042 A2. 53 pages.
Degen, R.J., F. Bejarano-Castillo, P. Rodríguez-Acosta, H Trimino-Vásquez (2013) “Load Bearing Wall Formwork System and Method” United States Patent - Publication Number US 8,468, 764 B2. 28 pages.
Degen, R.J., F. Bejarano-Castillo, H Trimino-Vásquez, P. Rodríguez-Acosta, (2014) “Concrete Flooring System Formwork Assembly Having Triangular Support Structure” United States Patent - Publication Number US 8,707,644 B2. 36 pages.

Luis Villegas:

Syedd, R., Solano, F., Campos, J., Pereira, D., Villegas, L., Hernández, N., & Sandoval, M. (2022). Fungal Extracellular Lipases From Coffee Plantation Environments for the Sustainable Management of Coffee Biomass. Biomass, 2(2), 62–79. https://doi.org/10.3390/biomass2020005
Mora-Villalobos, J.-A., Aguilar, F., Carballo-Arce, A.-F., Vega-Baudrit, J.-R., Trimino-Vazquez, H., Villegas-Peñaranda, L. R., Stöbener, A., Eixenberger, D., Bubenheim, P., Sandoval-Barrantes, M., & Liese, A. (2021). Tropical agroindustrial biowaste revalorization through integrative biorefineries—review part I: coffee and palm oil by-products. Biomass Conversion and Biorefinery. https://doi.org/10.1007/s13399-021-01442-9
Syedd-León, R., Sandoval-Barrantes, M., Trimiño-Vásquez, H., Villegas-Peñaranda, L. R., & Rodríguez-Rodríguez, G. (2020). Revisiting the fundamentals of p-nitrophenol analysis for its application in the quantification of lipases activity. A graphical update. Uniciencia, 34(2), 31–42. https://doi.org/10.15359/RU.34-2.2
Valdés, S., Garita, C., Esquivel, C., & Villegas-Peñaranda, L. R. (2020). Aislamiento y purificación de la enzima lacasa : evaluación de su potencial biodegradador en residuos agrícolas. Revista BioTecnología, 24(2), 29–45. https://smbb.mx/wp-content/uploads/2020/08/6-Valdes-et-al-2020.pdf
Lundgren, B. R., Villegas-Peñaranda, L. R., Harris, J. R., Mottern, A. M., Dunn, D. M., Boddy, C. N., & Nomura, C. T. (2014). Genetic analysis of the assimilation of C5-Dicarboxylic acids in pseudomonas aeruginosa PAO1. Journal of Bacteriology, 196(14), 2543–2551. https://doi.org/10.1128/JB.01615-14 (Factor de impacto 2020: 3,16)
Lundgren, B. R., Thornton, W., Dornan, M. H., Villegas-Peñaranda, L. R., Boddy, C. N., & Nomura, C. T. (2013). The Gene PA2449 is Essential for Glycine Metabolism and Pyocyanin Biosynthesis in Pseudomonas aeruginosa PAO1. Journal of Bacteriology, 195(9), 2087–2100. https://doi.org/10.1128/JB.02205-12
Stevens, D. C., Conway, K. R., Pearce, N., Villegas-Peñaranda, L. R., Garza, A. G., & Boddy, C. N. (2013). Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli. PloS One, 8(5), e64858. https://doi.org/10.1371/journal.pone.0064858
Alpízar, J., Villegas-Peñaranda, L. R., Madrigal, S., & Ballestero, M. (2013). Effect of pineapple (ananas comosus) culture by-products on the enzymatic deproteinization of shrimp biowastes. Uniciencia, 27, 156–170.
Cordero, M., Borbon, H., Roman, F. R., Víquez, R., Villegas-Peñaranda, L. R., Soto, R., Vega, I., & Jacqueline, H. (2012). Antimicrobial Activity and Phytochemical Screening of Secondary Metabolites Extracted from the Ascidian Rhopalaea Birkelandi. European Journal of Scientific Research, 70(3), 345–353.
Cordero, M., Borbon, H., Roman, F. R., Morell, L., Víquez, R., Villegas-Peñaranda, L. R., Soto, R., & Vega, I. (2011). Chemical and functional characterization of antimicrobial metabolites isolated from the ascidian Rhopalaea birkelandi. Revista Ciencias Marinas y Costeras, 3, 111–125. http://www.revistas.una.ac.cr/index.php/revmar/article/view/3288
Alfaro, G. & Villegas-Peñaranda, L. R. Tercer Informe Estado de la Educación: La educación científica en Costa Rica. (2010).

Carlos Cartín:

Cabrera-Rodríguez, C. I., Cartin-Caballero, C. M., Platarou, E., de Weerd, F. A., van der Wielen, L. A., & Straathof, A. J. (2018). Recovery of acetate by anion exchange with consecutive CO2-expanded methanol desorption: A model-based approach. Separation and Purification Technology, 203, 56-65

Manuel Sandoval:

Syedd-León, R., Solano-Campos, F., Campos-Rodríguez, J., Pereira-Arce, D., Villegas-Peñaranda, L.R., and Sandoval-Barrantes, M. (2022) Fungal extracellular lipases from coffee plantation environ-ments for the sustainable management of agro-industrial coffee biomass. Biomass, MDPI, (In press).
Mora-Villalobos, JA., Aguilar, F., Carballo-Arce, AF. et al. Tropical agroindustrial biowaste revalorization through integrative biorefineries—review part I: coffee and palm oil by-products. Biomass Conv. Bioref. (2021). https://doi.org/10.1007/s13399-021-01442-9
Syedd-León, R., Sandoval-Barrantes, M., Trimiño-Vasquez Humberto, Villegas-Peñaranda, L.R and Rodríguez-Rodríguez, G. (2020) Revisiting the fundamentals of p-nitrophenol analysis for its application in the quantification of lipases activity. A graphical update. Uniciencia. Vol 30. N° 2. July-December, 2020. http://dx.doi.org/10.15359/ru.34-2.2
Gómez-Jiménez, A., Porro, S., Sandoval-Barrantes, M. (2017) Propuesta metodológica para el análisis de las actividades en los libros de texto de ciencias naturales. Revista RBBA: Revista Binacional Brasil Argentina. Volumen 6 Número 2. https://doi.org/10.22481/rbba.v6i2.3675 Farrán, A., Cai, C., Sandoval, M., Xu, Y. Liu, J., Hernáiz, M.J., Linhardt, J. (2015) Green solvents in carbohydrate chemistry: from raw materials to fine chemicals. Chemical Reviews. 115 (14). Pp. 6811-6853 https://doi.org/10.1021/cr500719h

Alcántara, A.R., Pace, V., Hoyos, P., Sandoval M., Holzen, W., and Hernáiz, M.J. (2014) Chemoenzymatic synthesis of carbohydrates as antidiabetic and anticancer drugs. Current Topics in Medicinal Chemistry, Vol. 14 (23) . Pp 2694-2711
DOI: 10.2174/1568026614666141215151056
Hernaiz, M. J.; Sandoval, M.; Hoyos, P.; Cortes-Cabrera, A.; Bavaro, T.; Terreni, M. (2014) RSC Advances. Development of regioselective deacylation of peracetylated ß-D-monosaccharides using lipase from Pseudomonas stutzeri under sustainable conditions. RSC Advances.4. Pp. 55495-55502 https://doi.org/10.1039/C4RA10401C
Pérez-Sánchez, M., Sandoval, M., Hernáiz, M.J., Domínguez de María, P. (2013) Biocatalysis in biomass-derived solvents: The quest for fully sustainable chemical processes. Current Organic Chemistry. 17, (11) pp. 1188-1199 http://dx.doi.org/10.2174/1385272811317110006
Sandoval, M. Civera, C., Berenguer, J., García-Blanco, F., y Hernáiz, M.J. (2013) Optimised N-acetyl-D-lactosamine synthesis using Thermus thermophilus β-galactosidase in bio-solvents. Tetrahedron. Vol 69. Issue 3. Pp. 1148–1152. https://doi.org/10.1016/j.tet.2012.11.053
Syedd, R., Madrigal, A., Sandoval, M., Vega-Baudrit, J. (2013) Impacto nacional e internacional en la promoción de las vocaciones científicas del Programa Mejoramiento de la Enseñanza de la Química. Uniciencia. Vol 27 (1)
Pérez-Sánchez M., Sandoval M. y Hernáiz M.J.(2012). Bio-solvents change regioselectivity in the synthesis of disaccharides using Biolacta β-galactosidase. Tetrahedron. 68, 2141-2145 https://doi.org/10.1016/j.tet.2012.01.020
Sandoval M., Ferreras E., Pérez-Sánchez M., Berenguer J., Sinisterra J.V., Hernáiz M.J.(2012). Screening of strains and recombinant enzymes from Thermus thermophilus for their use in disaccharide synthesis. Journal of Molecular Catalysis B: Enzymatic. 74, 162-169 https://doi.org/10.1016/j.molcatb.2011.09.012
Sandoval M., Civera C., Treviño J., Ferreras E., Cortés A., Vaultier M., Berenguer C., Lozano P., Hernáiz M. J. (2012) Efficient and selective enzymatic synthesis of N-Acetyl-Lactosamine in ionic liquid: a rational explanation. RSC Advances, 2, 6306-6314. https://doi.org/10.1039/C2RA20618H
Pérez M., Sandoval M., Cortés A., García H., Sinisterra J.V., García, J.I., Hernáiz M.J. (2011). Solvents derived from glycerol modify classical regioselectivity in the enzymatic synthesis of disaccharides with Biolacta β-galactosidase. Green Chemistry. 13, 2810-2817. https://doi.org/10.1039/C1GC15266A

Yohana Alfaro Acuña:

Rodrigo Velasco-Bucheli 1,y , Daniel Hormigo 1,z , Jesús Fernández-Lucas 1,z , Pedro Torres-Ayuso 1,§, Yohana Alfaro-Ureña 1, Ana I. Saborido 1, Lara Serrano-Aguirre 1, José L. García 2, Fernando Ramón 1,k, Carmen Acebal 1, Antonio Santos 3 , Miguel Arroyo 1, and Isabel de la Mata 1,*, 1 Department of Biochemistry, Penicillin Acylase from Streptomyces lavendulae and Aculeacin A Acylase from Actinoplanes tahensis: Two Versatile Enzymes as Useful Tools for Quorum Quenching Processes. Catalysts 2020, 10, 730 (Junio 2020).
Jesús Fernandez-Lucas ´ a,b , Ivan Acebr ´ on´ c , Ruiying Y. Wu d , Yohana Alfaro e , Javier Acosta a , Pierre A. Kaminski f , Miguel Arroyo e , Andrzej Joachimiak c,g,h , Boguslaw P. Nocek d , Isabel De la Mata e , Jos´e M. Mancheno˜ c,*, 1 Department of Biochemistry, Biochemical and structural studies of two tetrameric nucleoside2′-deoxyribosyltransferases from psychrophilic and mesophilic bacteria:Insights into cold-adaptation. International Journal of Biological Macromolecules 192 (2021) 138–150 (October 2021).